Supports healthy estrogen metabolism
D-glucarate supports Phase II glucuronidation, a primary detoxification pathway that deactivates toxins and promotes their elimination. D-glucarate plays a vital protective role for the immune system by inhibiting the beta-glucuronidase enzyme that can otherwise interfere with safe removal of steroid hormones such as estrogen. Beta-glucuronidase enzymes are active throughout the body, especially in the liver, colon, lungs, skin, bladder, breast, and prostate.
|Serving Size 1 Capsule
|Amount Per Capsule
|% Daily Value
|Calcium (as calcium D-glucarate)
|* Daily value not established
Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, and silicon dioxide
1 capsule, 1 to 3 times daily with food or as directed by a healthcare professional.
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and yeast. Contains no artificial colors, flavors, or preservatives.
If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. KEEP OUT OF REACH OF CHILDREN.
What is Calcium D-Glucarate?
Calcium D-Glucarate is a patented form of D-glucarate (also known as D-glucaric acid), a naturally occurring substance in the body that is involved in the metabolism and disposal of toxins and excess hormones, such as estrogen. In the diet, D-glucarate is found primarily in fruits and vegetables such as apples, grapefruit, oranges, bean sprouts, and broccoli. It is also produced in small amounts in the body.
What does Calcium D-Glucarate do?
Studies show that Calcium D-Glucarate supplementation supports healthy immune function, promotes estrogen metabolism, and enhances the body's detoxification systems through inhibition of beta-glucuronidase, an enzyme that can interfere with normal hormone metabolism.
How does Calcium D-Glucarate work?
Upon ingestion, D-glucarate is slowly released from Calcium D-Glucarate and forms a compound that inhibits the enzyme beta-glucuronidase. This enzyme reduces the excretion of toxins and steroid hormones, including estrogen. Although beta-glucuronidase has some useful functions in the body, it can become overactive as a result of shifts in the gut microbiome, allowing toxins and hormones to be reabsorbed back into the body instead of being excreted. The slow-release nature of Calcium D-Glucarate inhibits about 50% of the enzyme activity over a five-hour period, thus helping the body to safely remove undesirable amounts of estrogen and other compounds. Because beta-glucuronidase enzymes are present in the liver, kidney, spleen, intestines, reproductive organs, and many other tissues, the beneficial actions of Calcium D-Glucarate may occur throughout the body.
Who should take Calcium D-Glucarate?
Anyone concerned about assisting the body's natural detoxifying ability can take Calcium D-Glucarate as it is a very safe, well-tolerated compound. It is especially suitable for individuals with routine exposure to environmental agents who wish to ensure an added measure of protection beyond that provided by antioxidants. Calcium D-Glucarate may be especially important for women concerned about maintaining healthy breast tissue.
How much Calcium D-Glucarate should I take?
The amount needed varies between individuals. For general daily use, 1 500 mg capsule daily is sometimes recommended. Research on Calcium D-Glucarate demonstrating inhibition of beta-glucuronidease begins with amounts of 1,500 mg per day and goes up to 9 grams per day. Individuals with higher environmental exposures, or increased needs to metabolize estrogen or other hormones, can take 3 or more capsules per day. The appropriate amount will be determined by your healthcare professional.