P-5-P Plus withMagnesium 100 capsules

P-5-P PLUS

Pyridoxal 5'-Phosphate with chelated magnesium

100 VEGETARIAN CAPSULES

Pyridoxal 5'-Phosphate (P-5-P, or PLP) is the biologically active form of vitamin B₆. It is formulated with highly bioavailable bisglycinate magnesium, an essential mineral that assists in B₆ metabolism. Magnesium bisglycinate chelate is well tolerated and easily and comfortably absorbed without GI tissue irritation. P-5-P Plus is a unique formula designed to support the health and function of the brain, nervous system, blood vessels, skin, and eyes.

Supplement Facts

Other Ingredients:

Vegetarian capsule (hydroxypropyl methylcellulose, water) and ascorbyl palmitate.

Albion and TRAACS are registered trademarks of Albion Laboratories, Inc.

Suggested Use

1 capsule daily with food or as directed by a healthcare professional.

Allergy Statement

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and yeast. Contains no artificial colors, flavors, or preservatives.

Caution

If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. KEEP OUT OF REACH OF CHILDREN.

FAQs

What is pyridoxal 5'-phosphate (P-5-P)?

Pyridoxal 5'-phosphate (P-5-P) is the active coenzyme form of vitamin B₆ that is directly utilized by the body. Vitamin B₆ naturally occurs in 3 major chemical forms: pyridoxine, pyridoxal, and pyridoxamine. While each of these forms has vitamin activity, only P-5-P (also called PLP) has an active coenzyme function in the body. P-5-P plays an important role in amino acid metabolism, neurotransmitter production, and a variety of other metabolic reactions. Non-P-5-P forms of vitamin B₆ are generally converted to P-5-P before being utilized in the body.

How does P-5-P compare to other forms of B₆ such as pyridoxine hydrochloride?

Although pyridoxine hydrochloride is the most commonly used form of vitamin B₆ in dietary supplements, and the best-studied, it must be converted to the active coenzyme form, P-5-P, to be utilized by the body. In certain clinical settings, subjects responded better to P-5-P than to pyridoxine, suggesting that they had less ability to convert pyridoxine to P-5-P. In contrast, vitamin B₆ as P-5-P is already fully "active" and readily usable, as it does not require further transformation in the body.

Is there any scientific documentation that supports enhanced bioavailability of P-5-P over pyridoxine hydrochloride?

Currently, little research exists comparing the efficacy of pyridoxal 5'-phosphate with other forms of vitamin B₆ such as pyridoxine. In certain clinical settings, subjects responded better to P-5-P than to pyridoxine, suggesting that they had less ability to convert pyridoxine to P-5-P. Although further research is certainly warranted, available research studies suggest P-5-P may be an optimal way to support vitamin B₆ levels and actions in the body, in particular for individuals who cannot convert pyridoxine, such as those requiring the vitamin for B₆-dependent red blood cell formation, B₆-dependent neurological function, and individuals on the spectrum.

Why is magnesium added to the P-5-P Plus formulation?

Magnesium is included to assist vitamin B₆ metabolism. Metabolic functions such as amino acid metabolism and neurotransmitter production require both magnesium and P-5-P. In addition, these 2 nutrients are frequently found as cofactors for the same enzymes.

Is P-5-P Plus a hypoallergenic product?

Yes, P-5-P Plus is free of milk, casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, yeast, and soy and contains no artificial additives, colorings, flavoring, preservatives, or salicylates.