CNS Factor 120 veggie capsules 500 milligrams

CNS Factor

Details

NeuroFactor

120 x 500mg capsules

Product Overview

CNS Factor is a clinically formulated blend of Euphoria longana, Houttuynia cordata, Dioscorea japonica with Schisandra chinensis (Schisandrin B). The NeuroFactor combination of Euphoria longana, Houttuynia cordata and Dioscorea japonica has been researched to exert antidepressant effects and increase Brain-derived neurotrophic factor (BDNF) levels in the brain. Schisandra a well- known adaptogen and cognitive aid, has been included for its antioxidant-neuroprotective, mood balancing and anti-inflammatory effects.

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• Maintains a healthy cellular response
• Supports antioxidant activity
• Promotes natural defenses to tissue invasion

Supplement Facts Serving Size: 2 capsules Servings Per Container: 50
	Amount Per Serving	% Daily Value
Dimocarpus longan (fruit)	111 mg	†
Dioscorea japonica (root)	111 mg	†
Houttuynia cordata (herb top)	111 mg	†
Schisandra chinensis (Schisandrin B) ethanol extract (fruit)	167 mg	†
†Daily Value not established.

Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.

Key Ingredients / Research

BDNF

References

1 Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 2015 Dec 10; 11(6): 1164- 1178. doi: 10.5114/aoms.2015.56342

2 Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 2015 Dec 10; 11(6): 1164- 1178. doi: 10.5114/aoms.2015.56342

NeuroFactor Formulation Research

References

3 Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S, Iyo M: Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003, 54:70-75.

4 Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM: Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002, 109:143-148.

5 Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S: Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005, 255:381-386.

6 Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S, Iyo M: Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003, 54:70-75.

7 Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S: Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005, 255:381-386.

8 Yoshimura R, Mitoma M, Sugita A, Hori H, Okamoto T, Umene W, Ueda N, Nakamura J: Effects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2007, 31:1034- 1037.

9 Lee HY, Kim YK: Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants. Neuropsychobiology 2008, 57:194-199.

10 Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN: Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003, 60:804- 815.

11 Huang TL, Lee CT, Liu YL: Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants. J Psychiatr Res 2008, 42:521-525.

12 Réus GZ, Stringari RB, Ribeiro KF, Ferraro AK, Vitto MF, Cesconetto P, Souza CT, Quevedo J: Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Behav Brain Res 2011, 221:166-171.

13 Smith MA, Makino S, Kvetnansky R, Post RM: Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 1995, 15:1768-1777.

14 Ueyama T, Kawai Y, Nemoto K, Sekimoto M, Toné S, Senba E: Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain. Neurosci Res 1997, 28:103-110.

15 Marmigère F, Givalois L, Rage F, Arancibia S, Tapia-Arancibia L: Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus 2003, 13:646-655.

16 Wolf OT: HPA axis and memory. Best Pract Res Clin Endocrinol Metab 2003,

17:287-299.

17 Kitraki E, Kremmyda O, Youlatos D, Alexis M, Kittas C: Spatial performance and corticosteroid receptor status in the 21-day restraint stress paradigm. Ann N Y Acad Sci 2004, 1018:323-327.

Euphoria Longan research

References

18 Parka SJ, Park DH, Kima DH, Lee S, Yoona BH, Junga WY, Lee KT, Cheongc JH, Ryua JH. The memory-enhancing effects of Euphoria longan fruit extract in mice. Journal of Ethnopharmacology 128 (2010) 160-165. doi:10.1016/j.jep.2010.01.001

19 Chen J, Chen X, Qin J. Effects of polysaccharides of the Euphoria Longan (Lour.) Steud on focal cerebral ischemia/reperfusion injury and its underlying mechanism. Brain Injury, March 2011; 25(3): 292-299

Houttuynia cordata research

References

20 Chen, YY, Liu, JF, Chen, CM, Chao, PY, Chang, TJ. A study of the antioxidative and antimutagenic effects of Houttuynia cordata Thunb. using an oxidized frying oil-fed model. J Nutr Sci Vitaminol, 2003;49;327-333.

21 Toda, S. Antioxidative effects of polyphenols in leaves of Houttuynia cordata on protein fragmentation by copper-hydrogen peroxide in vitro. J. Med. Food, 2005;8;266-268.

22 Nuengchamnong, N, Krittasilp, K, Ingkaninan, K. Rapid screening and identification of antioxidants in aqueous extracts of Houttuynia cordata using LC-ESI-MS coupled with DPPH assay. Food Chem, 2009;117;750-756.

23 Shin, S, Joo, SS, Jeon, JH, Park, D, Jang, MJ, Kim, TO, Kim, HK, Hwang, BY, Kim, KY, Kim, YB. Anti-inflammatory effects of a Houttuynia cordata supercritical extract. J Vet Sci, 2010;11;273-275.

24 Tian, L, Zhao, Y, Guo, C, Yang, X. A comparative study on the antioxidant activities of an acidic polysaccharide and various solvent extracts derived from herbal Houttuynia cordata. Carbohydr Polym, 2011;83;537-544.

25 Shi L, Dong R, Ji J. Effect of Herba Houttuyniae injection on the ability of learning and memory of mice. 2004. J Southeast University.

26 Park H, Oh MS. Houttuyniae Herba protects rat primary cortical cells from A?(25-35)-induced neurotoxicity via regulation of calcium influx and mitochondria-mediated apoptosis. Hum Exp Toxicol. 2012;31:698-709.

27 Zhao B. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochem Res. 2009;34:630-638.

28 Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. Differential protection among fractionated blueberry polyphenolic families against DA-, A?(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells. J Agric Food Chem. 2010;58:8196-8204.

29 Zhang L, Zhang WP, Chen KD, Qian XD, Fang SH, Wei EQ. Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury. Life Sci. 2007;80:530-537.

30 Huang SM, Chuang HC, Wu CH, Yen GC. Cyto-protective effects of phenolic acids on methylglyoxal-induced apoptosis in Neuro-2A cells. Mol Nutr Food Res. 2008;52:940-949.

31 Kwon SH, Lee HK, Kim JA, Hong SI, Kim HC, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholiesterase and anti-oxidative activities in mice. Eur J Pharmacol. 2010;649:210-217.

32 Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA. Protective effect of quercetin in primary neurons against A?(1-42): relevance to Alzheimer's disease. J Nutr Biochem. 2009;20:269-275.

33 Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, Raza SS, Javed H, Vaibhav K, Khan A, Islam F. Rutin protects the neural damage induced by transient focal ischemia in rats. Brain Res. 2009;1292:123-135.

34 Huh E, Kim HG, Park H, Kang MS, Lee B, Oh MS. Houttuynia cordata Improves Cognitive Deficits in Cholinergic Dysfunction Alzheimer's Disease-Like Models. Biomol Ther (Seoul). 2014 May; 22(3): 176-183.

doi: 10.4062/biomolther.2014.040

Dioscorea japonica research

References

35 Kim KH, Kim MA, Moon E, Kim SY, Choi SZ, Son MW, Lee KR. Furostanol saponins from the rhizomes of Dioscorea japonica and their effects on NGF induction. Bioorganic & Medicinal Chemistry Letters 21 (2011) 2075-2078. doi:10.1016/j.bmcl.2011.02.003

Schisandra (Sch B) Research

References

36 Hu, XL, Guo C, Hou JQ, et al. Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3? Inhibitors with Neuroprotective Effects against Alzheimer's Disease: Stereochemistry and Biological Activity. ACS Chemical Neuroscience, 2018. doi:10.1021/acschemneuro.8b00252

37 Ming Zhang, Hong-xia Zheng, Yang-yang Gao, Bo Zheng, Jing-ping Liu, He Wang, Zhan-jun Yang & Zhi-ying Zhao. The influence of Schisandrin B on a model of Alzheimer's disease using ?-amyloid protein A?1-42-mediated damage in SH-SY5Y neuronal cell line and underlying mechanisms. Journal of Toxicology and Environmental Health, Part A, (2017), DOI: 10.1080/15287394.2017.1367133

38 Minyu Zhang, Liping Xu and Hongjun Yang. Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases

Int. J. Mol. Sci. 2018, 19, 1970; doi:10.3390/ijms19071970

39 Minyu Zhang, Liping Xu and Hongjun Yang. Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases

Int. J. Mol. Sci. 2018, 19, 1970; doi:10.3390/ijms19071970

40 Ke-Wu Zeng, Tai Zhang, Hong Fu, Geng-Xin Liu, Xue-Mei Wang. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-?B signaling pathway in lipopolysaccharide-induced microglia. European Journal of Pharmacology, Volume 692, Issues 1-3, 5 October 2012, Pages 29-37, https://doi.org/10.1016/j.ejphar.2012.05.030

41 Yang Q, Li N, Sui X et al. Study on neuroprotective effect of schisandrin B by regulating the A? and its downstream NF- ?B/TNF-? pathway. China Journal of Traditional Chinese Medicine and Pharmacy, 2017-05, http://en.cnki.com.cn/Article_en/CJFDTOT AL-BXYY201705038.htm

42 Ba Q, Cui C, Wen L, Feng S, Zhou J, Yang K. Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson's disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway. Biomed Pharmacother. 2015 Oct;75:165-72. doi: 10.1016/j.biopha.2015.07.034.

43 D.Q. Xin, Z.M. Hu, H.J. Huo, X.J. Yang, D. Han, W.H. Xing, Y. Zhao, and Q.H. Qiu. Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats. Mol Med Rep. 2017 Jul; 16(1): 533-538. doi: 10.3892/mmr.2017.6622

44 Pou Kuan Leong Kam Ming Ko. Schisandrin B induces an Nrf2?mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo. BioFactors, Volume 41, Issue 5, September/October 2015. Pages 314-323. https://doi.org/10.1002/biof.1224

45 Minyu Zhang, Liping Xu and Hongjun Yang. Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases. Int. J. Mol. Sci. 2018, 19, 1970; doi:10.3390/ijms19071970

46 Giridharan, V.V.; Thandavarayan, R.A.; Arumugam, S.; Mizuno, M.; Nawa, H.; Suzuki, K.; Ko, K.M.; Krishnamurthy, P.; Watanabe, K.; Konishi, T. Schisandrin B Ameliorates ICV-Infused Amyloid beta Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-kappaB/MAPK and Up-Regulating HSP/Beclin Expression. PLoS ONE 2015, 10, e0142483.

47 Liu, N.; Zheng, J.X.; Zhuang, Y.S.; Zhou, Z.K.; Zhao, J.H.; Yang, L. Anti-Inflammatory Effects of Schisandrin B on LPS- Stimulated BV2 Microglia via Activating PPAR-gamma. Inflammation 2017, 40, 1006-1011.

48 Zeng, K.W.; Zhang, T.; Fu, H.; Liu, G.X.; Wang, X.M. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-kappaB signaling pathway in lipopolysaccharide-induced microglia. Eur. J. Pharmacol. 2012, 692, 29-37.

49 Lee, T.H.; Jung, C.H.; Lee, D.H. Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. Food Chem Toxicol. 2012, 50, 4239-4245.

50 He LI, Ning LI, Cong LIU, Jiale LIU, Mengyang WANG, Wenyue ZHUANG, Chunmei WANG, Jinghui SUN, Jianguang CHEN. Antianxiety effect of schisandrin B in ICR mice and its mechanism. Journal of Jilin University(Medicine Edition) 2018;44(1):78- 82 http://wprim.whocc.org.cn/admin/article/articleDetail?WPRIMID=691528&articleId=692013

51 Li N, Liu J, Wang M, et al. Sedative and hypnotic effects of Schisandrin B through increasing GABA/Glu ratio and upregulating the expression of GABAA in mice and rats. Biomedicine & Pharmacotherapy, Volume 103, July 2018, Pages 509- 516 https://doi.org/10.1016/j.biopha.2018.04.017

52 Sowndhararajan K, Deepa P, Kim M, Park SJ,Kim S. An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis. Biomedicine & Pharmacotherapy 97 (2018) 958-968. http://dx.doi.org/10.1016/j.biopha.2017.10.145

53 Zhang M, Xu L, and Hongjun Yang H. Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases. Int. J. Mol. Sci. 2018, 19, 1970; doi:10.3390/ijms19071970

54 Chen Z, Guo M, Song G, et al. Schisandrin B inhibits Th1/Th17 differentiation and promotes regulatory T cell expansion in mouse lymphocytes. International Immunopharmacology, Volume 35, June 2016, Pages 257-264 https://doi.org/10.1016/j.intimp.2016.03.037

55 Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RAJO, Bromberg E, de Vries EFJ. Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation. Mol Neurobiol. 2

Suggested Use:

1-2 capsules BID

Caution:

Caution in pregnancy.

Schisandra may affect medications metabolized by the liver enzymes Cytochrome P450 1A2, 2C9, 3A4, and 3A5 substrates: medications changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and warfarin (Coumadin). The doses of the medication might need to be changed.

Schisandra may have inhibitory effects on the liver enzyme Cytochrome P450 3A4. Medications metabolized by CYP 450 3A4 include Alprazolam (Xanax), amlodipine (Norvasc), atorvastatin (Lipitor), cyclosporine (Sandimmune), diazepam (Valium), estradiol (Estrace), simvastatin (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien)

Warfarin (Coumadin) interacts with schisandra: Warfarin (Coumadin) is used to slow blood clotting. The body breaks down warfarin (Coumadin) to get rid of it. Schisandra might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Anti-epileptic drugs: Benzodiazepines are one of the most common. NeuroFactor is an agonist and will cause drowsiness, and therefore needs to be monitored.

May increase effect of Benzodiazepine drugs however, it's not contraindicated. Schisandra has been used for Benzodiazepine withdrawal.

Supports SSRIs.

P-glycoprotein substrates: Lab and human studies suggest schisandra can inhibit Pgp activity and may interfere with the metabolism of certain drugs.

Tacrolimus: In liver transplant patients, schisandra increased blood levels of tacrolimus, an immunosuppressant.

DOES NOT CONTAIN: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts