Brand: Panaxea

Flexible 60 veggie capsules

In Stock

Product Description

Panaxea Flexible

Flexible is a Joint Health Blend with Clinically Tested Extracts to improve joint mobility.

What Flexible is Best For

Flexible is recommended for people with joint inflammation,swelling and pain.

Flexible may be used for the following:

Relieves pain
Reduces joint inflammation and swelling
Improves joint mobility
Anticoagulant

How Flexible Works

Joint stiffness and discomfort is also a consequence of aging. With advancing age, there's an increase in certain cytokines (immune-modulating agents) that contribute to bone health conditions. Tumor necrosis factor (TNF-alpha) is one such agent. These pro-inflammatory agents have been implicated in a host of age-related problems including issues related to joints.

Panaxea's FLEXIBLE Formula combines clinically proven plant extracts into one powerful formula to help ease inflammation. FLEXIBLE formula provides scientifically validated botanical extracts that have been shown to have significant salutary effects on joint health.

Flexible Serving Size

2 capsules 2 - 3 x daily

Flexible Ingredients

Serving Size: 1 capsule

Servings Per Container: 60

Amount Per Serving		% Daily Value
Notopterygium incisium	156 mg	†
Angelica pubescens	78 mg	†
Gentiana macrophylla	38 mg	†
Curcumin	78 mg	†
Morus alba	156 mg	†
Piper kadsura	156 mg	†
Angelica polymorpha	78 mg	†
Ligusticum sinense	78 mg	†
Boswellia carterii	46 mg	†
Inula helenium	76 mg	†
Cinnamomum cassia	38 mg	†
Glycyrrhiza uralensis	22 mg	†

† Daily Value not established.

Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.

Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts

Suggested Use

Caution: If pain persists consult your health practitioner

Warning: Contraindicated with pregnancy and lactation.

Key Ingredients

Curcumin

Curcumin is a compound that is universally recognized for its impressive antioxidant and fluid-regulating properties. Curcumin was reported to have anticancer, antiviral, antiarthritic, antioxidant, and antiinflammatory pharmacological properties, and curcumin has been linked with suppression of various cancers, inflammation, diabetes, diseases of the cardiovascular and neurological systems. Recent studies also showed that curcumin has antinociceptive effects on several painful diseases, such as peripheral nerve injury-induced neuropathic pain, diabetic peripheral neuralgia, postoperative pain, and inflammatory pain. (1)

Shaosheng et al (2014) reported that curcumin attenuated type 2 diabetes neuropathic pain in male Sprague-Dawley rates. The effect of curcumin on pain maybe related to expression of MMP-2 and MMP-9 in the spinal dorsal horn and dorsal root ganglion. (2)

References

1. Zhang Li; Hou Na; Xiang Yong. Research Progress in Analgesic Effects of Curcumin. Yi Xue Zong Shu, 2015, (16): 2986-2988.

2. Wu Shaosheng, Sun Chuanfeng, Cao Hong, Li Jiajia, Shi Xiaoting, Li Jun. Effect of curcumin on expression of MMP-2 and MMP-9 in spinal dorsal horn and dorsal root ganglion of rats with type 2 diabetic neuropathic pain. Zhong Hua Ma Zui Xue Za Zhi, 2014, (11): 1339-1342.

Angelica pubescens (Du Huo)

Researchers extracted Angelica pubescens (AP) with various solvents in order to find the bioactive constituents that demonstrated analgesic and anti-inflammatory effects. The results revealed that the anti-inflammatory and analgesic constituents from roots of AP were related to peripheral inhibition of inflammatory substances and to the influence on the central nervous system. (1)

Researchers tested Angelica Pubescens' volatile oil for its potential effect on inflammation and pain. Their results suggested that Radix Angelicae pubeascentis' volatile oil has anti-inflammatory and analgesic effects. (2)

References

1. Yuh-Fung Chen1 , Huei-Yann Tsai, Tian-Shung Wu Anti-Inflammatory and Analgesic Activities from Roots of Angelica pubescens Planta Med 1995; 61(1): 2-8?DOI: 10.1055/s-2006-957987

2. FAN Li, LI lin, HE Hui-feng. Pharmacological studies on anti-inflammatory and analgesic effects of Radix Angelicae pubescentis? s volatile oil. An Hui Yi Yao, 2009, (2): 133-134.

Notopterygium incisium (Qiang Huo)

Notoptergium, endemic to high altitude regions, is mainly distributed in Tibet, Sichuan, Qinghai and Gansu of China. Its main chemical constituents are coumarins, phenoloids and essential oils. Pharmacological studies have indicated that coumarins, such as notopterol, bergapten and isoimperatorin, found in Notopterygium possess anti-inflammatory, analgesic, anti-cancer and anti-coagulant activities [1-3) and the volatile oils possess antifebrile, anodyne and anti-inflammatory activities [4].

References

1. Garcia-Argaiez, A.N.; Ramarez Apan, T.O.; Parra Delgado, H.; Velaizquez, G.; Martanez-Vaizquez, M. Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model. Planta Med. 2000, 66, 279-281.

2. Keri, R.S.; Hosamani, K.M.; Shingalapur, R.V.; Hugar, M.H. Analgesic, anti-pyretic and DNA cleavage studies of novel pyrimidine derivatives of coumarin moiety. Eur. J. Med. Chem. 2010, 45, 2597-2605.

3 Wu, S.B.; Pang, F; Wen, Y.; Zhang, H.F.; Zhao, Z; Hu, J.F. Antiproliferative and apoptotic activities of linear furocoumarins from Notopterygium incisum on cancer cell lines. Planta Med. 2010, 76, 82-85.

4. Xu, H.B.; Sun, X.B.; Zhao, Q.C. Pharmacological research on the volatile oil of Notopterygium incisum. Chin. Tradit. Herb. Drugs 1991, 22, 28-31.

Morus alba (Sang Zhi)

The foliage of Morus alba (M. alba) has remained the primary food for silkworms for centuries. With flavonoids as major constituents, mulberry leaves possess various biological activities, including antioxidant, antimicrobial, cytotoxic, anti-diabetic, glucosidase inhibition, anti-hyperlipidemic, anti-atherosclerotic, anti-obesity, cardioprotective, and cognitive enhancement activities. Rich in anthocyanins and alkaloids, M. alba fruits have pharmacological properties, such as antioxidant, anti-diabetic, anti-atherosclerotic, anti-obesity, and hepatoprotective activities. The root bark of M. alba, containing flavonoids, alkaloids and stilbenoids, has antimicrobial, skin-whitening, cytotoxic, anti-inflammatory, and anti-hyperlipidemic properties.

Other pharmacological properties of M. alba include anti-platelet, anxiolytic, anti-asthmatic, anthelmintic, antidepressant, cardioprotective, and immunomodulatory activities. Clinical trials on the efficiency of M. alba extracts in reducing blood glucose and cholesterol levels and enhancing cognitive ability have been conducted. Overall, M. alba is a multi-functional plant with promising medicinal properties (1).

References

1. Eric Wei-Chiang CHAN, Phui-Yan LYE, Siu-Kuin WONG, Phytochemistry, pharmacology, and clinical trials of Morus alba, Chinese Journal of Natural Medicines, Volume 14, Issue 1, 2016, Pages 17-30, ISSN 1875-5364,

Inula Helenium (Mu Xiang)

Inula helenium L. is an herb with anti-inflammatory properties. Sesquiterpene lactones (SLs), mainly alantolactone (AL) and isoalantolactone (IAL), are considered as its active ingredients.

Chemical analysis showed that AL and IAL represent major constituents of TSL-IHL. TSL-IHL, as well as AL and IAL, could inhibit TNF-?-induced activation of NF-?B and MAPK pathways in b. End3 cells, suppress the expressions of MMP-3, MCP-1, and IL-1 in TNF-?-stimulated synovial fibroblasts, and IL-1, IL-6, and iNOS in LPS-activated RAW 264.7 cells in a dose-dependent manner in the range of 0.6-2.4 g/mL. Oral administration of TSL-IHL at 12.5, '50 mg/kg could dose-dependently alleviate the arthritic severity and paw swelling in either developing or developed phases of arthritis of rats induced by adjuvant or collagen. (1)

References

1. Shuang Gao, Qun Wang, Xin-Hui Tian, Hui-Liang Li, Yun-Heng Shen, Xi-Ke Xu, Guo-Zhen Wu, Zhen-Lin Hu, Wei-Dong Zhang, Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis, Journal of Ethnopharmacology, Volume 196, 20 January 2017, Pages 39-46, ISSN 0378-8741, http://dx.doi.org/10.1016/j.jep.2016.12.020.

Boswellia carterii (Ru Xiang)

Many inflammatory diseases can be caused by leukotrienes, including asthma, colitis, rheumatism, arthritis, and psoriasis. (1) Boswellia has shown to be a specific inhibitor of leukotrienes. It acts by blocking the synthesis of leukotrienes and, therefore, inhibiting inflammation and shrinking the inflamed tissue which is the primary cause of pain and discomfort in many cases. (1)

Boswellia has shown to be effective in treating various inflammatory diseases, and based on data obtained from the experiments done in vitro and in vivo, boswellic acids are assumed to be the pharmacologically active principles of Boswellia (frankincense) which are responsible for the anti-inflammatory and anti-tumorigenic actions. (2)

References

1. Birkner KM. Pain and Stress Publications. San Antonio: Texas; 2006. Boswellia, The Pain Herb.

2. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M. Frankincense (R? Xi?ng; Boswellia Species): From the Selection of Traditional Applications to the Novel Phytotherapy for the Prevention and Treatment of Serious Diseases. Journal of Traditional and Complementary Medicine. 2013;3(4):221-226. doi:10.4103/2225-4110.119723.

Ligusticum wallichii

In a Japanese study, the active ingredients in Ligusticum, tetramethylpyrazine and ferulic acid, were found to have both significant antiinflammatory and analgesic effects. (1)

References

1.Ozaki Y. Antiinflammatory effect of tetramethylpyrazine and ferulic acid. Chem Pharm Bull 1992;40:954-956.

Cinnamomum cassia (Gui Zhi)

Xiao-hu et al (2011) explored the curative effects of Cinnamomum cassia in early- stage rheumatoid arthritis. (1)

In a rat model of arthritis Strobal, Ramulus Cinnamomi and their different compatible proportions all had the effects of relieving pain and inflammatory and free radical injury. The effect of compatible application of strobal and Ramulus Cinnamomi was significantly greater then only strobal or Ramulus Cinnamomi. Compatible application of strobal and Ramulus Cinnamomi has significantly synergistic effect on relieving pain, anti- inflammatory and against free radical injury. (2)

References

1. TANG Xiao - hu, JING Lan - hua, PENG Jiang - yun, WU Yang. Cassia Twig (guizhi) and Kind of Party in the Early Use of Rheumatoid Arthritis. Yun Nan Zhong Yi Xue Yuan Xue Bao, 2011, (6): 28-30

2. Sun Xueju, Ma Liancheng. Experimental study of compatible application of strobal and Ramulus Cinnamomi on adjuvant arthritis rats. Xian Dai Zhong Xi Yi Jie He Za Zhi, 2008, (14): 2124-2127.