De-Gen 60 capsules 500 milligrams

De-Gen

SKU: PAN99

De-Gen

60 x 500 mg Capsules

De-Gen is a botanical wonder, designed for all of us who are ageing (50+) and wish to alter the process of degeneration. Degeneration is the result of oxidative stress, elevated inflammatory factors and insulin resistance.

This degeneration is reversible with De-Gen proven by research to stop the ageing process through effecting glucose and lipid metabolism. De-Gen stops the formation of advanced glycation endproducts, oxidative stress, inflammation, and cellular apoptosis.

Actions

Brain Health

• Reduces the age-related memory decline
• Anti-Dementia - increases expression of brain-derived neurotrophic factor (BDNF)
• Reduces oxidative stress

Metabolic Health

• Down regulates glycation end products
• Regulates coagulation factors
• Reduces oxidative stress
• Regulates glucose and lipid metabolism
• Down regulates insulin resistance

Vital Organ protection

• Hepatoprotective - helps prevent liver cirrhosis
• Ameliorates development of age-related renal damage
• Down regulates advanced glycation end products

Anti-ageing

• Anti-inflammatory - Inhibits COX2
• Reduces oxidative stress

† Daily Value not established.

Does not contain: wheat, gluten, corn, yeast, soy, egg, dairy products, or artificial colors, artificial sweeteners, or artificial flavors. This product also does not contain lactose, palmitic acid, magnesium stearate, or stearic acid.

Other ingredients: Vegetable Capsule

Key Ingredients

De-Gen was reported to have a beneficial effect on aging and age-related disorders, such as metabolic syndrome and diabetes (Satoh et al., 2004, 2005; Yokozawa et al., 2006a,b, 2007). Moreover, it was shown to have affects on the glucose and lipid metabolism, advanced glycation endproducts formation, oxidative stress, inflammation, and apoptosis caused by hyperglycemia in type 2 diabetic liver and kidney (Yamabe et al., 2010; Noh et al., 2011; Okamoto et al., 2011; Park et al., 2012).

In addition, Salviae Miltiorrhizae Radix, a fundamental/principal component of this formulation, had protected effects against oxidative stress in SAMP1 mice and cellular senescence in human fibroblasts (Satoh et al., 2004, 2005; Yokozawa et al., 2006a).

This study focused on the effects of insulin resistant and oxidative stress-related inflammation in the kidneys of the old rats treated with De-Gen. The present study showed that the administration of De-Gen to old rats had a favorable influence on the prevention of renal failure progression, at least in part, by ameliorating the insulin resistant-related PI3K/Akt pathway-induced inflammation.

Whereas Salviae Miltiorrhizae Radix inhibited the MAPK pathway-related inflammatory cytokine expression in the kidney. Although the detailed mechanisms of De-Gen and Salviae Miltiorrhizae Radix were not clarified in the present study, these findings provide therapeutic evidence for the beneficial effects of De-Gen and Salviae Miltiorrhizae Radix on ameliorating the development of age-related renal damage.

In conclusion, old rats showed increased renal damage associated with the expression of the PI3K/Akt, MAPK pathway-derived pro- inflammatory transcription factors (NF-KB and AP-1), and pro-inflammatory genes (COX-2, iNOS, and TNF-a). On the other hand, these unfavorable outcomes were reversed by De-Gen or Salviae Miltiorrhizae Radix administration in old rats. De-Gen or Salviae Miltiorrhizae Radix treatment of old rats improved the overall renal function, such as serum urea nitrogen and morphological characteristics

Age-Related Senescence and Oxidative Stress

Inhibition of platelet aggregation, hypotensive effect, AGE formation, oxidative stress, Type 2 diabetes, anti-dyslipidemia and the recovery of memory deficits induced by senescence, as well as treatment of cardiovascular and cerebrovascular diseases

De-Gen, a formulation containing six herbs; Paeoniae Radix (bai shao), Cnidii Rhizoma (chuan xiong), Carthami Flos (hong hua), Cyperi Rhizoma (xiang fu), Aucklandiae Radix (mu xiang), and Salviae Miltiorrhizae Radix (dan shen), and is commonly used to treat the symptoms associated with blood stasis. This prescription has attracted considerable attentions because of its biological activities, such as the inhibition of platelet aggregation, hypotensive effect, and the recovery of memory deficits induced by senescence (Cho et al., 2008; Zhao et al., 2010; Park et al., 2014).

A study by Cho et al., (2007) examined whether De-Gen and its crude drug, Salviae Miltiorrhizae Radix, have a reno-protective effect on the age-related oxidative stress and inflammatory response through the phosphoinositide 3-kinase (PI3K)/Akt or mitogen-activated protein kinase (MAPK) pathways in aged rats. De-Gen or Salviae Miltiorrhizae Radix was administered orally to old groups of rats for 16 days, and their effects were compared with the vehicle-treated old and young rats. The administration of De-Gen caused a slight decrease in the serum glucose level and a significant decrease in the serum insulin level in the old rats. The increased levels of serum renal functional parameter (urea-nitrogen) and oxidative parameter were significantly reduced by both De-Gen and Salviae Miltiorrhizae Radix.

The old rats exhibited a dysregulation of the protein expression related to insulin resistance, oxidative stress, and inflammation in the kidneys, but De-Gen administration significantly reduced the expression of the inflammatory proteins through the PI3K/Akt pathway. On the other hand, the Salviae Miltiorrhizae Radix-treated old rats showed a decrease in the inflammatory cytokines through the MAPK pathway. These results provide important evidence that De-Gen and Salviae Miltiorrhizae Radix have a pleiotropic effect on the PI3K/Akt and MAPK pathways, showing renoprotective effects against the development of inflammation in old rats. This study provides scientific evidence that De-Gen and Salviae Miltiorrhizae Radix improve the inflammatory responses via the PI3K/Akt or MAPK pathways in the kidney of old rats.

Cho et al., (2007) focused on the effects of insulin resistant and oxidative stress-related inflammation in the kidneys of the old rats treated with De-Gen and Salviae Miltiorrhizae Radix. This study showed that the administration of De-Gen to old rats had a favorable influence on the prevention of renal failure progression, at least in part, by ameliorating the insulin resistant-related PI3K/Akt pathway-induced inflammation. Whereas Salviae Miltiorrhizae Radix inhibited the MAPK pathway-related inflammatory cytokine expression in the kidney. Although the detailed mechanisms of De-Gen and Salviae Miltiorrhizae Radix were not clarified in the present study, these findings provide therapeutic evidence for the beneficial effects of De-Gen and Salviae Miltiorrhizae Radix on ameliorating the development of age-related renal damage.

Old rats showed increased renal damage associated with the expression of the PI3K/Akt, MAPK pathway-derived pro-inflammatory transcription factors (NF-KB and AP-1), and pro-inflammatory genes (COX-2, iNOS, and TNF-a). On the other hand, these unfavorable outcomes were reversed by De-Gen or Salviae Miltiorrhizae Radix administration in old rats.

De-Gen showed favorable effects on hypertriglycemia, AGE formation, and oxidative stress in Streptozocin (STZ)-treated rats, suggesting beneficial effects on diabetes, diabetic hepatopathy, and liver diseases such as cirrhosis, as well as cardiovascular and cerebrovascular diseases. Results provide important evidence that De-Gen exhibits a pleiotropic effect on AGE formation and fibrosis-related parameters, representing hepato-protective and reno-protective effects against the development of diabetic complications in type 2 diabetic db/db mice (Kim et al., 2009). Findings by Hum et al., (2014) indicate that De-Gen exerts anti-dyslipidemia effects in adipocytes and type 2 diabetic db/db mice.

References and Sources

Cho EJ, Yokozawa T, Okamoto T. Protective effect of Chinese prescription De-Gen and its crude drug Tanjin against age-related lipidosis in rats. J Pharm Pharmacol. 2007 May;59(5):687-94.

Cho EJ, Okamoto T, Yokozawa T. Therapeutic efficacy of De-Gen against H2O2-induced premature senescence. J Pharm Pharmacol. 2008 Nov;60(11):1537-44. doi: 10.1211/jpp/60.11.0016.

Hum Park C, Young Rhyu D, Sook Noh J, Min Park C, Yokozawa T. Effectiveness of Chinese prescription De-Gen for dyslipi-demia, using 3T3-L1 adipocytes and type 2 diabetic mice. Drug Discov Ther. 2014;8(3):121-31.

Kim HY, Okamoto T, Yokozawa T. Beneficial effects of Chinese prescription

De-Gen on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2009 Jul 15;124(2):263-9. doi: 10.1016/j.jep.2009.04.032.

Noh JS, Park CH, Kim HY, Zhao Q, Yamabe N, Matsumoto K, Yokozawa T. Chinese prescription De-Gen prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. J Pharm Pharmacol. 2011 Jan;63(1):111-9. doi:10.1111/j.2042-7158.2010.01156.x.

Okamoto T, Park CH, Noh JS, Toriizuka K, Sei Y, Park JC, Yokozawa T. Hepato-/reno-protective activity of Chinese prescription De-Gen through inhibition of AGE formation and fibrosis-related protein expression in type 2 diabetes. Pharm Pharmacol. 2011 Jul;63(7):952-9. doi: 10.1111/j.2042-7158.2011.01299.x.

Park CH, Noh JS, Okamoto T, Park JC, Yokozawa T. Evaluation of Effects of Chinese Prescription De-Gen on Diabetes-Induced Alterations such as Oxidative Stress and Apoptosis in the Liver of Type 2 Diabetic db/db Mice. Evid Based Complement Alternat Med. 2012;2012:143489. doi: 10.1155/2012/143489.

Park CH, Kim DH, Park MH, et al. Chinese prescription De-Gen and Salviae Miltiorrhizae Radix improve age-related oxidative stress and inflammatory response through the PI3K/Akt or MAPK pathways. Am J Chin Med. 2014;42(4):987-1005. doi: 10.1142/S0192415X14500621.

Satoh A, Yokozawa T, Cho EJ, Okamoto T, Sei Y. Antioxidative effects related to the potential anti-aging properties of the Chinese prescription De-Gen and Carthami Flos in senescence-accelerated mice. Arch Gerontol Geriatr. 2004 Jul-Aug;39(1):69-82.

Satoh A, Yokozawa T, Kim YA, Cho EJ, Okamoto T, Sei Y. The mechanisms underlying the anti-aging activity of the Chinese prescription De-Gen in hydrogen peroxide-induced human fibroblasts. J Pharm Pharmacol. 2005 Oct;57(10):1335-43.

Yamabe N, Kim HY, Kang KS, Zhao Q, Matsumoto K, Yokozawa T. Effect of Chinese prescription De-Gen on lipid metabolism in type 2 diabetic db/db mice. J Ethnopharmacol. 2010 Jun 16;129(3):299-305. doi: 10.1016/j.jep.2010.03.032.

Yokozawa T, Cho EJ, Okamoto T, Sei Y. Effects of the Chinese prescription De-Gen and its crude drug Tanjin on ageing process in rats. J Pharm Pharmacol. 2006 Dec;58(12):1591-9.

Yokozawa T, Kim HJ, Yamabe N, Okamoto T, Cho EJ. The protective role of De-Gen against fructose-induced metabolic syndrome in a rat model. J Pharm Pharmacol. 2007 Sep;59(9):1271-8.

Zhao Q, Yokozawa T, Yamabe N, Tsuneyama K, Li X, Matsumoto K. De-Gen improves memory deficit caused by aging through normalization of neuro-plasticity-related signaling system and VEGF system in the brain. J Ethnopharmacol. 2010 Sep 15;131(2):377-85. doi: 10.1016/j.jep.2010.07.016.

Suggested Use

2 capsules a daily

Caution: Do not use if pregnant or likely to become pregnant

Warning: None noted