Brand: Microbiome Labs

MegaSporeBiotic 180 capsules

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Product Description

About MegaSporeBiotic

MegaSporeBiotic by Microbiome Labs is a 100% spore-based probiotic blend with potent antioxidant properties that have been clinically shown to maintain a healthy gut and improve the immune system. The broad-spectrum probiotic blend is actually the first of its kind that has been evidenced to improve leaky gut by 60% in 30 days.

It is a unique spore formula that contains a blend of 5 Bacillus spores which are found to boost gastrointestinal immunity. Their bi-phasic life cycle* enables them to remain in sleep mode when in a harsh environment and reactivate themselves when they enter the human digestive tract or another favorable environment. MegaSporeBiotic is the first, all spore, pharmaceutical grade probiotic that uses what nature offers to create a great probiotic that helps improve immune function. MegaSporeBiotic comes with a 5-year shelf-life and can preserve the efficacy of its ingredients without requiring refrigeration.

*This refers to Bacillus spores’ inherent survivability that allows them to shift from a dormant form into their active form (and vice versa) depending on the environment. That is how they manage to survive digestion without needing refrigeration or enteric-coated capsules. When in their dormant form, they surround themselves with a tough outer layer called endospore that protects them from environmental factors such as lack of oxygen, acid, pressure, heat, and light.

How MegaSporeBiotic Works

MegaSporeBiotic is an all spore forumula probiotic that effectively reconditions the gut by improving microbial diversity and maintaining key health-promoting, commensal gut bacteria. Reconditioning instead of reseeding with probiotic strains, which is what most probiotics do, is a better option as many strains of probiotics cannot survive digestion.

The problems start when chronic inflammatory conditions are left untreated or go undiagnosed. Most of the time, the intestinal tissues get damaged, which leads back to inflammation and then tissue damage and so on - a cycle that never ends. The first step towards helping those damaged intestinal tissues heal is to recondition the intestinal tract, that is where MegaSporeBiotic comes in.

MegaSporeBiotic contains probiotic strains that have been proven to slow or stop the growth of bacteria and yeast while creating a stronger immune response and producing nutrients the body needs at the site of absorption.

The Three Aspects of Gut Health

To function properly and enjoy a healthy function, the gut microbiome relies heavily upon three fundamental factors:

  • The physical structures
  • The microbial population
  • The regulatory immune system

If one of the three is malfunctioning, the gastrointestinal health and digestive system can be adversely affected. For that reason, it is critical to follow therapies that address all three aspects of gut health and provide a complete restoration of its normal function. Microbiome Labs’ Total Gut Restoration system has been specifically designed to provide healthcare practitioners with the tools they need to combat chronic diseases effectively.

This system comprises of:

The first factor affecting GI tract health (reconditioning) is addressed appropriately with MegaSporeBiotic, as described above. Once this is achieved, the next step is to promote a diverse and strong microbiome by reinforcing the changes that have occurred. Increasing the growth of primary strains, such as Bifidobacteria or Faecalibacterium prausnitzii is key in this case. That is what MegaPreBiotic does, the first Precision Prebiotic supplement that comprises of oligosaccharides (non-digestible and clinically-tested) which feed beneficial bacteria and improve microbial diversity.

The final step is to ensure the intestinal lining remains healthy and protected. Rebuilding the mucosal layer is a prerequisite here, which will also help heal the intestinal barrier function. The same brand has formulated MegaMucosa for that purpose, which comes packed with key amino acids, dairy-free immunoglobulins, and a specific flavobiotic that combats leaky gut (aka barrier dysfunction).

What is Leaky Gut Syndrome?

This digestive condition affecting the lining of the intestines or increased by intestinal permeability. This happens when large holes or cracks in the intestinal lining allows partially digested foods, toxins, and bugs to penetrate the tissues beneath it. Inflammation and changes in gut flora can lead to digestive issues and extend to the rest of the body - possibly playing a part in several chronic diseases.

MegaSporeBiotic Ingredients

The formula for MegaSporeBiotic contains a total of five Bacillus spores:

Bacillus Licheniformis produces a full spectrum of B vitamins, as well as proteases (enzymes that break down peptides and proteins) for the proper digestion of proteins.

Bacillus Indicus HU36 produces vitamins, quinols, and RDA carotenoids levels (lutein, B-carotene, astaxanthin, lycopene).

Bacillus Subtilis HU58 fosters the healthy development of an enzyme called GALT which helps break down sugar. In addition, Bacillus Subtilis HU58 produces vitamin K2 and nattokinase, which is an an enzyme that boosts reactions in the human body.

Bacillus Clausii is an immune function-supporting Bacillus spore that also helps sustain efficacy during antibiotic treatment.

Bacillus Coagulans protects the immune system function and produces a specific form of lactic acid (L+ optical).

Serving Size

The recommended serving size of MegaSporeBiotic is 1 capsule every other day with food. Take this amount for a week, and then increase to 1 capsule every day. Finally, at week 3 you should be taking 2 capsules a day. The goal is to slowly increase your intake to 2 capsules daily.


  • In some cases, you may need to start with ¼ MegaSporeBiotic capsule every other day and slowly work your way to 2 capsules per day.
  • If you experience changes in the bowel movements, loose stools, and/or abdominal cramping, do not worry. It means that the formula is doing its job. The symptoms will go away in a couple of days.
  • Sensitive individuals or children may require a smaller dosage.


  • Soy-free
  • Allergen-free
  • GMO-free
  • Dairy-free
  • Gluten free
  • Non-GMO
  • The only probiotic product that includes HU36TM or Bacillus Indicus - a spore that produces lycopene, astaxanthin, zeaxanthin, beta-carotene and lutein - carotenoids in the GI tract.
  • 100% survivability in the gastric system
  • Does not require refrigeration
  • Boasts a 5-year shelf life
  • Maintains efficacy during antibiotic therapy

Are spore based probiotics better?

Yes, spore form probiotics like Megaspore are a better option than traditional probiotics because of their ability to survive harsh environments like the gastrointestinal tract. The spores are considered a dormant spore allowing them survive the digestive system until a more favorable environment is found at which time they will move to an active, vegetative form and start to colonize the gut.

About Microbiome Labs

Microbiome Labs is a supplement manufacturing company founded by microbiologists Kiran Krishnan and Dr. Tom Bayne. The two professionals combined their clinical expertise and probiotic research and formulated the first gut health-promoting supplement after discovering Bacillus spores, which is considered the next big probiotic in the supplement industry. Their mission is to make vibrant health accessible to everybody. So far, they have helped more than 334,000 people change their lives.